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If the buprenorphine dose is inadequate as well as CYP3A4 inducer can not be decreased or discontinued, changeover the client again to a buprenorphine formulation that permits dose adjustments.Contraindicated (1)pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4